Homogentisate phytyltransferase activity is limiting for tocopherol biosynthesis in Arabidopsis.

@article{Collakova2003HomogentisatePA,
  title={Homogentisate phytyltransferase activity is limiting for tocopherol biosynthesis in Arabidopsis.},
  author={Eva Collakova and Dean DellaPenna},
  journal={Plant physiology},
  year={2003},
  volume={131 2},
  pages={
          632-42
        }
}
Tocopherols are essential components of the human diet and are synthesized exclusively by photosynthetic organisms. These lipophilic antioxidants consist of a chromanol ring and a 15-carbon tail derived from homogentisate (HGA) and phytyl diphosphate, respectively. Condensation of HGA and phytyl diphosphate, the committed step in tocopherol biosynthesis, is catalyzed by HGA phytyltransferase (HPT). To investigate whether HPT activity is limiting for tocopherol synthesis in plants, the gene… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 63 REFERENCES

Biosynthesis of isoprenoid quinones and chromanols

DR Threlfall, GR Whistance
  • 1971
VIEW 17 EXCERPTS
HIGHLY INFLUENTIAL

Genetic dissection of carotenoid synthesis in Arabidopsis defines plastoquinone as an essential component of phytoene desaturation

Norris, X Shen, D DellaPenna
  • Plant Cell
  • 1995
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Seed-specific overexpression of phytoene synthase: increase in carotenoids and other metabolic effects

  • The Plant journal : for cell and molecular biology
  • 1999
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Isolation and characterization of homogentisate phytyltransferase genes from Synechocystis sp . PCC 6803 and Arabidopsis

M Schledz, A Seidler, P Beyer, G Neuhaus
  • Plant Physiol
  • 2002

Isolation of an Arabidopsis mutant lacking vitamin E and identification of a cyclase essential for all tocopherol biosynthesis

WA Pryor
  • Proc Natl Acad Sci USA
  • 2002

The function of tocopherols and tocotrienols in plants

WC Neely, JM Martin, SA Barker
  • Crit Rev Plant Sci
  • 2002