Homogeneity of 16S-23S ribosomal intergenic spacer regions of Tropheryma whippelii in Swiss patients with Whipple's disease.

@article{Hinrikson1999HomogeneityO1,
  title={Homogeneity of 16S-23S ribosomal intergenic spacer regions of Tropheryma whippelii in Swiss patients with Whipple's disease.},
  author={Hans Peter Hinrikson and Fabrizio Dutly and M. Altwegg},
  journal={Journal of clinical microbiology},
  year={1999},
  volume={37 1},
  pages={152-6}
}
The current genetic strategies used to identify Tropheryma whippelii, the putative agent of Whipple's disease, are based on PCR-mediated amplification of a part of its 16S rRNA gene (16S rDNA). Because there is very little intraspecies variation in these molecules, they are not suitable as targets for epidemiologic investigations. However, the intergenic spacer region between the 16S and 23S rDNAs is usually much more variable and has repeatedly been used for epidemiologic purposes. We have… CONTINUE READING

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