Homoflavonoid glucosides from Ophioglossum pedunculosum and their anti-HBV activity.

@article{Wan2011HomoflavonoidGF,
  title={Homoflavonoid glucosides from Ophioglossum pedunculosum and their anti-HBV activity.},
  author={Chuanxing Wan and Ping-Hu Zhang and Jianguang Luo and Ling-Yi Kong},
  journal={Journal of natural products},
  year={2011},
  volume={74 4},
  pages={
          683-9
        }
}
Chemical investigation of the ethanolic extracts of the whole plant of Ophioglossum pedunculosum afforded seven new homoflavonoid glucosides, pedunculosumosides A-G (1-7). Pedunculosumosides A and C exhibit modest activity of blocking HBsAg secretion with IC(50) values of 238.0 and 70.5 μM, respectively. 
Two new homoflavonoids from the fern Ophioglossum pedunculosum
TLDR
Two new homoflavonoids were isolated from the fern Ophioglossum pedunculosum Desv and the possible biogenetic pathway to compounds 1 and 2 was discussed.
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An updated review of the literature on the occurrence, chemotaxonomy and physiological activity of fern secondary metabolites is provided, covering recent findings concerning the bioactive phytochemicals and pharmacology of f Fern species.
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Two new glycosylated and acylated flavonols were isolated from the aerial parts of the fern Ophioglossum vulgatum L and found to be active in scratch-wound healing assays on keratinocytes, with 3 being the most active one and showing maximum activity at 20 µM.
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Data suggest that 1 acts through a Ca2+-dependent, nongenomic mechanism involving the activation of ERK1/2 MAP kinase, which is a main candidate to explain the wound healing virtues of O. vulgatum ointment and is proposed as a possible new drug in tissue repair and regenerative medicine.
3‐O‐Methylquercetin Glucosides from Ophioglossum pedunculosum and Inhibition of Lipopolysaccharide‐Induced Nitric Oxide Production in RAW 264.7 Macrophages
The three new 3-O-methylquercetin glucosides 1–3, together with three known congeners and 3-O-methylquercetin, were isolated from the fern Ophioglossum pedunculosum
Characterisation of homoflavonoids from three Ophioglossum species using liquid chromatography with diode array detection and electrospray ionisation tandem mass spectrometry.
TLDR
The HPLC-DAD-ESI/MS(n) method obtained in the present study provided a powerful tool for identifying homoflavonoids from ferns in the genus Ophioglossum.
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