Homoflavonoid glucosides from Ophioglossum pedunculosum and their anti-HBV activity.

  title={Homoflavonoid glucosides from Ophioglossum pedunculosum and their anti-HBV activity.},
  author={Chuanxing Wan and Ping-Hu Zhang and Jianguang Luo and Ling-Yi Kong},
  journal={Journal of natural products},
  volume={74 4},
Chemical investigation of the ethanolic extracts of the whole plant of Ophioglossum pedunculosum afforded seven new homoflavonoid glucosides, pedunculosumosides A-G (1-7). Pedunculosumosides A and C exhibit modest activity of blocking HBsAg secretion with IC(50) values of 238.0 and 70.5 μM, respectively. 
Two new homoflavonoids from the fern Ophioglossum pedunculosum
Two new homoflavonoids were isolated from the fern Ophioglossum pedunculosum Desv and the possible biogenetic pathway to compounds 1 and 2 was discussed.
Phenolic constituents from the aerial parts of Glycyrrhiza inflata and their antibacterial activities
  • Biao Zhou, C. Wan
  • Chemistry, Medicine
    Journal of Asian natural products research
  • 2015
The analysis of structure–activity relationships revealed that the antibacterial activity of dihydroflavanones (2–9) was significantly affected by the position of prenyl group.
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3‐O‐Methylquercetin Glucosides from Ophioglossum pedunculosum and Inhibition of Lipopolysaccharide‐Induced Nitric Oxide Production in RAW 264.7 Macrophages
The three new 3-O-methylquercetin glucosides 1–3, together with three known congeners and 3-O-methylquercetin, were isolated from the fern Ophioglossum pedunculosum
Characterisation of homoflavonoids from three Ophioglossum species using liquid chromatography with diode array detection and electrospray ionisation tandem mass spectrometry.
The HPLC-DAD-ESI/MS(n) method obtained in the present study provided a powerful tool for identifying homoflavonoids from ferns in the genus Ophioglossum.


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Six homoflavonoids isolated from Ophioglossum petiolatum, together with five known compounds, quercetin, luteolin, kaempferol, 3,5,7,3',4'-pentahydroxy-8-prenylflavone, and quercETin 3-O-methyl ether, were elucidated by analysis of spectroscopic data and chemical evidence.
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