Homodimerization of the Wnt receptor DERAILED recruits the Src family kinase SRC64B.

@article{Petrova2013HomodimerizationOT,
  title={Homodimerization of the Wnt receptor DERAILED recruits the Src family kinase SRC64B.},
  author={Iveta M. Petrova and Liza L. Lahaye and Tania Marti{\'a}{\~n}ez and Anja W. M. de Jong and Martijn J. A. Malessy and Joost Verhaagen and Jasprina N. Noordermeer and Lee G. Fradkin},
  journal={Molecular and cellular biology},
  year={2013},
  volume={33 20},
  pages={4116-27}
}
Ryk pseudokinase receptors act as important transducers of Wnt signals, particularly in the nervous system. Little is known, however, of their interactions at the cell surface. Here, we show that a Drosophila Ryk family member, DERAILED (DRL), forms cell surface homodimers and can also heterodimerize with the two other fly Ryks, DERAILED-2 and DOUGHNUT ON 2… CONTINUE READING