Homodimerization of UDP-glucuronosyltransferase 2B7 (UGT2B7) and identification of a putative dimerization domain by protein homology modeling.

Abstract

Although homodimerization of UGT1A proteins is well established, direct evidence for dimerization of UGT2B7, which is arguably the most important enzyme involved in human drug glucuronidation, is currently lacking. This study characterized UGT2B7 homodimerization by co-immunopreciptation and generated a UGT2B7 homology model that identified the dimerization… (More)
DOI: 10.1016/j.bcp.2011.09.007

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Cite this paper

@article{Lewis2011HomodimerizationOU, title={Homodimerization of UDP-glucuronosyltransferase 2B7 (UGT2B7) and identification of a putative dimerization domain by protein homology modeling.}, author={Benjamin C Lewis and Peter I. Mackenzie and John O. Miners}, journal={Biochemical pharmacology}, year={2011}, volume={82 12}, pages={2016-23} }