Homocysteinylated Albumin Promotes Increased Monocyte-Endothelial Cell Adhesion and Up-Regulation of MCP1, Hsp60 and ADAM17

@inproceedings{Capasso2012HomocysteinylatedAP,
  title={Homocysteinylated Albumin Promotes Increased Monocyte-Endothelial Cell Adhesion and Up-Regulation of MCP1, Hsp60 and ADAM17},
  author={Rosanna Capasso and Irene Sambri and Amelia Cimmino and Sofia Salemme and Cinzia Lombardi and Filomena Acanfora and Ersilia Satta and Donald L. Puppione and Alessandra F Perna and Diego Ingrosso},
  booktitle={PloS one},
  year={2012}
}
RATIONALE The cardiovascular risk factor homocysteine is mainly bound to proteins in human plasma, and it has been hypothesized that homocysteinylated proteins are important mediators of the toxic effects of hyperhomocysteinemia. It has been recently demonstrated that homocysteinylated proteins are elevated in hemodialysis patients, a high cardiovascular risk population, and that homocysteinylated albumin shows altered properties. OBJECTIVE Aim of this work was to investigate the effects of… CONTINUE READING

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