Homocysteine upregulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo.

@article{Zhang2012HomocysteineUS,
  title={Homocysteine upregulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo.},
  author={Donghong Zhang and Xina Xie and Yequn Chen and Bruce D Hammock and Wei Kong and Yi Zhu},
  journal={Circulation research},
  year={2012},
  volume={110 6},
  pages={
          808-17
        }
}
RATIONALE Hyperhomocysteinemia is a risk factor of atherogenesis. Soluble epoxide hydrolase (sEH) is a major enzyme that hydrolyzes epoxyeicosatrienoic acids and attenuates their cardiovascular protective effects. Whether homocysteine (Hcy) regulates sEH and the underlying mechanism remains elusive. OBJECTIVE To elucidate the mechanism by which Hcy regulates sEH expression and endothelial activation in vitro and in vivo. METHODS AND RESULTS Hcy treatment in cultured human endothelial cells… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 48 CITATIONS

Dysregulation of Epigenetic Mechanisms of Gene Expression in the Pathologies of Hyperhomocysteinemia

  • International journal of molecular sciences
  • 2019
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Hyperhomocysteinaemia and vascular injury: advances in mechanisms and drug targets.

  • British journal of pharmacology
  • 2017
VIEW 4 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 34 REFERENCES

Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2009

Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2007