Homocysteine stimulates the production and secretion of cholesterol in hepatic cells.

@article{Karmin1998HomocysteineST,
  title={Homocysteine stimulates the production and secretion of cholesterol in hepatic cells.},
  author={O Karmin and Edward G Lynn and Yee H. Chung and Yaw Chris Siow and Ricky Y. K. Man and Patrick C. Choy},
  journal={Biochimica et biophysica acta},
  year={1998},
  volume={1393 2-3},
  pages={317-24}
}
Homocysteinemia and hypercholesterolemia are important risk factors associated with the occurrence of arteriosclerotic vascular diseases. A positive correlation between plasma levels of homocysteine and cholesterol was found in homocysteinemic patients as well as in experimental animals. In the present study, the effect of homocysteine on the production and secretion of cholesterol in human hepatoma cell line HepG2 cells was investigated. When cells were incubated with 4 mM homocysteine, the… CONTINUE READING