Homocysteine stimulates the expression of monocyte chemoattractant protein-1 in endothelial cells leading to enhanced monocyte chemotaxis

@article{Sung2001HomocysteineST,
  title={Homocysteine stimulates the expression of monocyte chemoattractant protein-1 in endothelial cells leading to enhanced monocyte chemotaxis},
  author={Fion Lan Sung and Yaw Chris Siow and Gu{\'o}p{\'i}ng W{\'a}ng and Edward G Lynn and O. Karmin},
  journal={Molecular and Cellular Biochemistry},
  year={2001},
  volume={216},
  pages={121-128}
}
Hyperhomocysteinemia has been identified as an independent risk factor for atherosclerosis. The infiltration of monocytes into the arterial wall is one of the key events during atherogenesis. Monocyte chemoattractant protein-1 (MCP-1) is a potent chemokine that stimulates the migration of monocytes into the intima of the arterial wall. The mechanism by which increased monocyte infiltration occurs in atherosclerotic lesions in patients with hyperhomocysteinemia has not been delineated. The… CONTINUE READING
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