Homocysteine stimulates inducible nitric oxide synthase expression in macrophages: Antagonizing effect of ginkgolides and bilobalide

  title={Homocysteine stimulates inducible nitric oxide synthase expression in macrophages: Antagonizing effect of ginkgolides and bilobalide},
  author={Connie W. Woo and F. Cheung and Vincent Chan and Y. L. Siow and O. Karmin},
  journal={Molecular and Cellular Biochemistry},
  • Connie W. Woo, F. Cheung, +2 authors O. Karmin
  • Published 2004
  • Chemistry, Medicine
  • Molecular and Cellular Biochemistry
  • Hyperhomocysteinemia is an independent risk factor for atherosclerotic diseases. Inducible nitric oxide synthase (iNOS) is mainly expressed in macrophages upon stimulation. Overproduction of nitric oxide (NO) by iNOS can exacerbate the development of atherosclerosis. Our previous studies demonstrated that the extract of ginkgo biloba leaves (EGb) inhibited the iNOS-mediated NO production in monocyte-derived macrophage. We also reported that homocysteine could stimulate monocyte chemoattractant… CONTINUE READING
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