Homocysteine metabolism is associated with cerebrospinal fluid levels of soluble amyloid precursor protein and amyloid beta.

@article{Oikonomidi2016HomocysteineMI,
  title={Homocysteine metabolism is associated with cerebrospinal fluid levels of soluble amyloid precursor protein and amyloid beta.},
  author={Aikaterini Oikonomidi and Piotr Lewczuk and Johannes Kornhuber and Yvo Michiel Smulders and Michael Linnebank and Alexander Semmler and Julius Popp},
  journal={Journal of neurochemistry},
  year={2016},
  volume={139 2},
  pages={324-332}
}
Disturbed homocysteine metabolism may contribute to amyloidogenesis by modulating the amyloid precursor protein (APP) production and processing. The objective of this study was to investigate the relationships between cerebral amyloid production and both blood and cerebrospinal fluid (CSF) markers of the homocysteine metabolism. We assessed CSF concentrations of soluble APPα, soluble APPβ, and amyloid β1-42 (Aβ1-42), as well as plasma levels of homocysteine (Hcys), total vitamin B12, and folate… CONTINUE READING