Homocysteine metabolism and cerebrospinal fluid markers for Alzheimer's disease.

  title={Homocysteine metabolism and cerebrospinal fluid markers for Alzheimer's disease.},
  author={Julius Popp and Piotr Lewczuk and Michael Linnebank and Gabriela Cvetanovska and Yvo Smulders and Heike Koelsch and Ingo Frommann and Johannes Kornhuber and Wolfgang Maier and Frank Jessen},
  journal={Journal of Alzheimer's disease : JAD},
  volume={18 4},
Disturbed homocysteine metabolism is a risk factor for Alzheimer's disease (AD) and may contribute to the disease pathophysiology by increasing both amyloid-beta (Abeta) production and phosphorylated tau (P-tau) accumulation. Here, we evaluated the relationship between the cerebrospinal fluid (CSF) concentrations of homocysteine (Hcys), S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), and 5-methyltetrahydrofolate (5-MTHF), and the markers for AD pathology, Abeta(1-42) and P-tau181, in… CONTINUE READING