Homocysteine-lowering trials for prevention of heart disease and stroke.

@article{Clarke2005HomocysteineloweringTF,
  title={Homocysteine-lowering trials for prevention of heart disease and stroke.},
  author={Robert J. Clarke},
  journal={Seminars in vascular medicine},
  year={2005},
  volume={5 2},
  pages={215-22}
}
Dietary supplementation with B-vitamins that lower plasma total homocysteine concentrations are expected to lower the risk of cardiovascular disease. Folic acid and vitamin B (12) lower blood homocysteine concentrations by about 25-30% in populations without folic acid fortification, but by only 10-15% in populations with fortification. In observational studies, 25% lower homocysteine is associated with about 10% less coronary heart disease (CHD) and about 20% less stroke. This review examines… CONTINUE READING

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