Homocysteine-lowering therapy and risk for venous thromboembolism: a randomized trial.

  title={Homocysteine-lowering therapy and risk for venous thromboembolism: a randomized trial.},
  author={Joel G. Ray and Clive Kearon and Qilong Yi and Patrick J. Sheridan and Eva M. Lonn},
  journal={Annals of internal medicine},
  volume={146 11},
BACKGROUND Elevated total homocysteine levels are associated with a higher risk for venous thromboembolism. Whether decreasing homocysteine levels with vitamin therapy reduces the risk for venous thromboembolism is not known. OBJECTIVE To determine whether decreasing homocysteine levels alters the risk for symptomatic venous thromboembolism. DESIGN Secondary analysis of data from the randomized, placebo-controlled Heart Outcomes Prevention Evaluation 2 (HOPE-2) trial. SETTING 145 clinical… CONTINUE READING
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