Homocysteine level and coronary heart disease incidence: a systematic review and meta-analysis.

@article{Humphrey2008HomocysteineLA,
  title={Homocysteine level and coronary heart disease incidence: a systematic review and meta-analysis.},
  author={Linda L. Humphrey and Rongwei Fu and Kevin R Rogers and Michele Freeman and Mark Helfand},
  journal={Mayo Clinic proceedings},
  year={2008},
  volume={83 11},
  pages={
          1203-12
        }
}
OBJECTIVE To determine whether an elevated homocysteine level is an independent risk factor for the development of coronary heart disease (CHD) to aid the US Preventive Services Task Force in its evaluation of novel risk factors for incident CHD. METHODS Studies of homocysteine and CHD were identified by searching MEDLINE (1966 through March 2006). We obtained additional articles by reviewing reference lists from prior reviews, original studies, editorials, and Web sites and by consulting… 
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330 Citations
Highly Influential Citations
14
Background Citations
120
Methods Citations
6
Results Citations
10

330 Citations

Citation Type

Citation Type

Folate and risk of coronary heart disease: a meta-analysis of prospective studies.
Homocysteine levels and cardiovascular risk factors in children and adolescents: systematic review and meta-analysis.
TLDR
High homocysteine levels were weakly associated with overweight in children and adolescents in the reviewed cross-sectional studies, however, for the other traditional cardiovascular risk factors, the findings, although important, were inconclusive.
Homocysteine and reclassification of cardiovascular disease risk.
Homocysteine-lowering interventions for preventing cardiovascular events.
TLDR
This second update of this Cochrane Review found no evidence to suggest that homocysteine-lowering interventions in the form of supplements of vitamins B6, B9 or B12 given alone or in combination should be used for preventing cardiovascular events.
Exclusion of a case-control study from meta-analysis
TLDR
The meta-analysis showed a positive association between a moderately elevated homocysteine level and coronary heart disease independent of traditional cardiovascular risk factors and this results facilitate discussion of whether moderate hyperhomocysteinemia is a cardiovascular risk factor in the general population.
Homocysteine-lowering interventions for preventing cardiovascular events.
TLDR
Whether homocysteine-lowering interventions, provided to patients with and without pre-existing cardiovascular disease are effective in preventing cardiovascular events, as well as reducing all-cause mortality, and to evaluate their safety is evaluated.
Homocysteine lowering interventions for preventing cardiovascular events.
TLDR
There is no evidence to support the use of homocysteine-lowering interventions in people with or without pre-existing cardiovascular disease and randomised clinical trials assessing the effects of HLI for preventing cardiovascular events with a follow-up period of 1 year or longer suggest this.
Homocysteine Level and Risk of Abdominal Aortic Aneurysm: A Meta-Analysis
TLDR
A meta-analysis and systematic review suggested that Hcy significantly increased the risk of abdominal aortic aneurysm.
Emerging Risk Factors for Coronary Heart Disease: A Summary of Systematic Reviews Conducted for the U.S. Preventive Services Task Force
TLDR
The criteria a new risk factor must meet to be clinically useful for reclassifying intermediate-risk patients' risk for major CHD events are outlined and a series of systematic reviews were conducted to help the U.S. Preventive Services Task Force (USPSTF) determine which of 9 risk factors should be used to further stratify intermediate- risk patients.
Folic Acid Supplementation and the Risk of Cardiovascular Diseases: A Meta‐Analysis of Randomized Controlled Trials
TLDR
A greater benefit for CVD was observed among participants with lower plasma folate levels and without preexisting CVD and in studies with larger decreases in homocysteine levels, while folic acid supplementation had no significant effect on risk of coronary heart disease.
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References

SHOWING 1-10 OF 73 REFERENCES
Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis.
TLDR
This meta-analysis of observational studies suggests that elevated homocysteine is at most a modest independent predictor of IHD and stroke risk in healthy populations.
Serum total homocysteine and coronary heart disease.
TLDR
In the general population serum total homocysteine is an independent risk factor for CHD with no threshold level, and there was no thresholdlevel above which serum homocy steine is associated with CHD events.
A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes.
TLDR
Higher folic acid intake by reducing tHcy levels promises to prevent arteriosclerotic vascular disease and under different assumptions, 13,500 to 50,000 CAD deaths annually could be avoided.
Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis
TLDR
Whether the association of serum homocysteine concentration with ischaemic heart disease, deep vein thrombosis and pulmonary embolism, and stroke is causal and, if so, to quantify the effect of homocy Steine reduction in preventing them, there is strong evidence that the association between homocy steine and cardiovascular disease is causal.
Homocysteine and ischemic heart disease: results of a prospective study with implications regarding prevention.
TLDR
The epidemiological, genetic, and animal evidence together indicate that the association between serum homocysteine level and ischemic heart disease (IHD) is likely to be causal.
Homocysteine and risk of cardiovascular disease among postmenopausal women.
TLDR
Elevated levels of homocysteine moderately increased the risk of future cardiovascular disease among healthy postmenopausal US women, and self-reported multivitamin supplement use at study entry was associated with significantly reduced levels.
Serum total homocysteine and coronary heart disease: prospective study in middle aged men
TLDR
Serum total homocysteine is prospectively related to increased coronary risk and may also be related to geographical variation in coronary risk within Britain and strengthen the case for trials of total homocrysteine reduction with folate.
Serum Homocysteine in Relation to Mortality and Morbidity From Coronary Heart Disease: A 24-Year Follow-Up of the Population Study of Women in Gothenburg
TLDR
The study illustrates that long-term prospective studies might be necessary to show effects of homocysteine levels on AMI morbidity and mortality in women, and an independent risk factor for myocardial infarction.
Serum homocysteine and risk of coronary heart disease and cerebrovascular disease in elderly men: a 10-year follow-up.
TLDR
In a general population of elderly men, a high homocysteine level is common and is strongly associated with the prevalence of coronary heart disease and cerebrovascular disease and it is a strong predictive factor for fatal cerebroVascular disease in men without hypertension but less so for coronaryHeart disease.
Homocysteine and the Risk of Ischemic Stroke in a Triethnic Cohort: The Northern Manhattan Study
TLDR
Total Hcy elevations above 15 μmol/L are an independent risk factor for ischemic stroke, whereas mild elevations of tHcy of 10 to 15μmol/ L are less predictive.
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