Homocysteine is a protein amino acid in humans. Implications for homocysteine-linked disease.

  title={Homocysteine is a protein amino acid in humans. Implications for homocysteine-linked disease.},
  author={Hieronim Jakubowski},
  journal={The Journal of biological chemistry},
  volume={277 34},
Homocysteine is thought to be a non-protein amino acid. However, in vitro studies suggest that homocysteine is likely to be incorporated by indirect mechanisms into proteins in living organisms. Here I show that homocysteine is a protein amino acid in humans. Homocysteine bound by amide or peptide linkages (Hcy-N-protein) is present in human hemoglobin, serum albumin, and gamma-globulins. 1 molecule of homocysteine per 1000 or 1670 molecules of methionine was present in hemoglobin or albumin… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 63 extracted citations

Relationship between paraoxonase and homocysteine: crossroads of oxidative diseases

Archives of medical science : AMS • 2012
View 7 Excerpts
Highly Influenced

Protein homocysteinylation: a new mechanism of atherogenesis?

Postepy higieny i medycyny doswiadczalnej • 2005
View 4 Excerpts
Highly Influenced

Spontaneous Release of Human Serum Albumin S-Bound Homocysteine in a Thiol-Free Physiological Medium

International Journal of Peptide Research and Therapeutics • 2017
View 1 Excerpt
Highly Influenced

Homocysteine thiolactone affects protein ubiquitination in yeast.

Acta biochimica Polonica • 2013
View 5 Excerpts
Highly Influenced

Homocystamides promote free-radical and oxidative damage to proteins.

Proceedings of the National Academy of Sciences of the United States of America • 2010
View 12 Excerpts
Highly Influenced

At the very beginning of life on Earth: the thiol-rich peptide (TRP) world hypothesis.

The International journal of developmental biology • 2017
View 1 Excerpt

Similar Papers

Loading similar papers…