Homocysteine is a protein amino acid in humans. Implications for homocysteine-linked disease.

@article{Jakubowski2002HomocysteineIA,
  title={Homocysteine is a protein amino acid in humans. Implications for homocysteine-linked disease.},
  author={Hieronim Jakubowski},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 34},
  pages={30425-8}
}
Homocysteine is thought to be a non-protein amino acid. However, in vitro studies suggest that homocysteine is likely to be incorporated by indirect mechanisms into proteins in living organisms. Here I show that homocysteine is a protein amino acid in humans. Homocysteine bound by amide or peptide linkages (Hcy-N-protein) is present in human hemoglobin, serum albumin, and gamma-globulins. 1 molecule of homocysteine per 1000 or 1670 molecules of methionine was present in hemoglobin or albumin… CONTINUE READING
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