Homocysteine inhibits potassium channels in human atrial myocytes.

  title={Homocysteine inhibits potassium channels in human atrial myocytes.},
  author={Ben-zhi Cai and Dong-mei Gong and Yu Liu and Zhen-Wei Pan and Chao-qian Xu and Yun-long Bai and Guo-fen Qiao and Yan-jie Lu and Bao-feng Yang},
  journal={Clinical and experimental pharmacology & physiology},
  volume={34 9},
1. A large body of evidence indicates that elevated homocysteine (Hcy) levels portend an increased risk for atrial fibrillation. However, little is known about the electrophysiological effects of Hcy on atrial myocytes. The present study was conducted to investigate the direct effects of Hcy on ion channels in human atria. 2. Whole-cell patch-clamp techniques were used to record potassium currents in human atrial cells. 3. In human atrial myocytes, transient outward potassium currents were… CONTINUE READING


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