Homocysteine inhibits extra‐embryonic vascular development in the avian embryo

@article{Latacha2005HomocysteineIE,
  title={Homocysteine inhibits extra‐embryonic vascular development in the avian embryo},
  author={Kimberly S. Latacha and T. Rosenquist},
  journal={Developmental Dynamics},
  year={2005},
  volume={234}
}
A strong association exists between pregnancy loss and maternal elevations of the sulfur‐containing amino acid, homocysteine. Because extra‐embryonic vascular growth is critical to maintaining a normal pregnancy, we examined the effects of homocysteine on vessel development by exposing avian embryos to exogenous homocysteine during critical periods of vascular growth. These experiments demonstrated that homocysteine significantly reduced survival and decreased angiogenesis in the extra… Expand
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