Homocysteine induces tau hyperphosphorylation in rats.

  title={Homocysteine induces tau hyperphosphorylation in rats.},
  author={Yougen Luo and Xinwen Zhou and Xifei Yang and Jianzhi Wang},
  volume={18 18},
Epidemiological and clinical data suggest that homocysteine (Hcy) may increase the risk of Alzheimer's disease, but the underlying mechanisms are elusive. To investigate the effect of Hcy on phosphorylation of tau, we injected Hcy into the lateral cerebral ventricle of rats. We found that level of the hyperphosphorylated tau at PHF-1 (Ser396/404) and tau-1 (Ser198/199/202) epitopes was elevated prominently at 6, 9, and 12 h after the injection, and it was recovered to normal at 24 h… CONTINUE READING

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