Homocysteine-induced inhibition of nitric oxide production in platelets: a study on healthy and diabetic subjects

@article{Mutus2001HomocysteineinducedIO,
  title={Homocysteine-induced inhibition of nitric oxide production in platelets: a study on healthy and diabetic subjects},
  author={Bulent Mutus and R. A. Rabini and Roberto Staffolani and Raffaella Ricciotti and Paolo Fumelli and Natalia Moretti and Daniela Martarelli and Laura Mazzanti},
  journal={Diabetologia},
  year={2001},
  volume={44},
  pages={979-982}
}
The molecular mechanisms involved in the platelet activation observed in hyperhomocysteinemia are not known. We aimed to discover if homocysteine concentrations are associated with abnormal platelet nitric oxide production in healthy and diabetic subjects. The study cohort included 28 patients with Type I (insulin-dependent) diabetes mellitus, 30 patients with Type II (non-insulin-dependent) diabetes mellitus, and 34 healthy subjects. Homocysteine plasma concentrations were measured by high… CONTINUE READING

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