Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells.

@article{Outinen1999HomocysteineinducedER,
  title={Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells.},
  author={P A Outinen and Sudesh K Sood and Sebastian Pfeifer and Sushmita Pamidi and Thomas J. Podor and Juan Jenny Li and Jeffrey I Weitz and Richard C Austin},
  journal={Blood},
  year={1999},
  volume={94 3},
  pages={959-67}
}
Alterations in the cellular redox potential by homocysteine promote endothelial cell (EC) dysfunction, an early event in the progression of atherothrombotic disease. In this study, we demonstrate that homocysteine causes endoplasmic reticulum (ER) stress and growth arrest in human umbilical vein endothelial cells (HUVEC). To determine if these effects reflect specific changes in gene expression, cDNA microarrays were screened using radiolabeled cDNA probes generated from mRNA derived from HUVEC… CONTINUE READING