Homocysteine in patients with rheumatoid arthritis in relation to inflammation and B‐vitamin treatment

@article{Yxfeldt2003HomocysteineIP,
  title={Homocysteine in patients with rheumatoid arthritis in relation to inflammation and B‐vitamin treatment},
  author={A Yxfeldt and Solveig W{\aa}llberg-Jonsson and Johan Hultdin and Solbritt Rantap{\"a}{\"a}-Dahlqvist},
  journal={Scandinavian Journal of Rheumatology},
  year={2003},
  volume={32},
  pages={205 - 210}
}
Objectives: To investigate the effects of treatment with B vitamins on homocysteine (Hcy) levels in patients with RA, and to analyse the relationship between Hcy levels and inflammatory variables, and/or MTX treatment. Methods: Sixty‐two patients with RA and levels of Hcy ≥12 μmol/L were randomized to receive placebo or a combination of vitamins B6, B12 and folic acid. The patients were treated and evaluated in a double‐blind manner over 12 months. Results: The Hcy level decreased significantly… Expand
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Plasma total homocysteine level and methylenetetrahydrofolate reductase 677C>T genetic polymorphism in Japanese patients with rheumatoid arthritis
  • C. Fujimaki, H. Hayashi, +5 authors K. Itoh
  • Biology, Medicine
  • Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
  • 2009
TLDR
It is concluded that homocysteine might affect the inflammatory status of patients, and the MTHFR 677C>T SNP could be a predictive factor of hyperhomocysteinemia in patients with RA. Expand
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