Homocysteine in patients with rheumatoid arthritis in relation to inflammation and B‐vitamin treatment

  title={Homocysteine in patients with rheumatoid arthritis in relation to inflammation and B‐vitamin treatment},
  author={A Yxfeldt and Solveig W{\aa}llberg-Jonsson and Johan Hultdin and Solbritt Rantap{\"a}{\"a}-Dahlqvist},
  journal={Scandinavian Journal of Rheumatology},
  pages={205 - 210}
Objectives: To investigate the effects of treatment with B vitamins on homocysteine (Hcy) levels in patients with RA, and to analyse the relationship between Hcy levels and inflammatory variables, and/or MTX treatment. Methods: Sixty‐two patients with RA and levels of Hcy ≥12 μmol/L were randomized to receive placebo or a combination of vitamins B6, B12 and folic acid. The patients were treated and evaluated in a double‐blind manner over 12 months. Results: The Hcy level decreased significantly… Expand
Variation of homocysteine levels in rheumatoid arthritis patients: relationship to inflammation, cardiovascular risk factors, and methotrexate
In multivariate logistic regression analysis, current MTX use, levels of vitamin B12 and creatine, and Clinical Disease Activity Index (CDAI) appeared to be independent factors associated with hyperhomocysteinemia. Expand
Hyperhomocysteinemia in patients with Behçet’s disease: is it due to inflammation or therapy?
Increased use or accelerated catabolism of folate and vitamin B12 due to chronic inflammation and moderately increased tHcy concentrations related with deficiency of these cofactors, and immunosuppressive drug administration might be potential threats of vascular disease in Behçet’s disease. Expand
Atherothrombotic events in rheumatoid arthritis are predicted by homocysteine - a six-year follow-up study.
High Hcy levels (in addition to age, sex and diabetes) predicted AT event prospectively in patients with rheumatoid arthritis, and RA patients on folic acid had lower H Cy levels. Expand
Relationship between vitamin B12, homocysteine and oxidative stress in juvenile idiopathic arthritis -
Studies have showed that vitamin B12 deficiency can lead to oxidative stress without causing significant increase in homocysteine levels by its effects on cytokines, growth factors, nitric oxide metabolism, antioxidant enzymes and producing reactive oxygen species. Expand
Association between diet and treatment results in patients with rheumatoid arthritis and systemic lupus erythematosus
Diet may play a role in response to anti-rheumatic treatment in patients with RA and SLE, and associations between specific dietary nutrients and clinical outcomes are presented. Expand
Elevated plasma homocysteine and low vitamin B-6 status in nonsupplementing older women with rheumatoid arthritis.
Poor vitamin B-6 status and elevated plasma homocysteine concentrations were seen in older women with rheumatoid arthritis compared to healthy controls and may contribute to their increased risk of cardiovascular disease. Expand
An overview of the role of diet in the treatment of rheumatoid arthritis
There is good evidence to suggest that fish oil supplements may be helpful in relieving some symptoms, such as decreased morning stiffness, in those with long-standing rheumatoid arthritis. Expand
Intakes of Vitamin B6 and Dietary Fiber and Clinical Course of Systemic Lupus Erythematosus: A Prospective Study of Japanese Female Patients
Higher intake of vitamin B6 and dietary fiber may prevent the occurrence of active disease in SLE. Expand
Olive extract supplement decreases pain and improves daily activities in adults with osteoarthritis and decreases plasma homocysteine in those with rheumatoid arthritis
After a relatively short treatment with OVW, subjects with OA and RA reported decreased pain and improvement in activities of daily living and high homocysteine levels in patients with RA have been associated with higher rates of mortality from cardiovascular events. Expand
Plasma total homocysteine level and methylenetetrahydrofolate reductase 677C>T genetic polymorphism in Japanese patients with rheumatoid arthritis
  • C. Fujimaki, H. Hayashi, +5 authors K. Itoh
  • Biology, Medicine
  • Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
  • 2009
It is concluded that homocysteine might affect the inflammatory status of patients, and the MTHFR 677C>T SNP could be a predictive factor of hyperhomocysteinemia in patients with RA. Expand


Changes in plasma homocysteine in arthritis patients starting treatment with low-dose methotrexate subsequently supplemented with folic acid
  • O. Slot
  • Medicine
  • Scandinavian journal of rheumatology
  • 2001
It is concluded that treatment with MTX induces a significant rise in p-homocysteine that is neutralised by FA supplementation, and Supplementation with FA from the start of MTX treatment is recommended considering the increased risk of cardiovascular disease that is associated with elevated concentrations of p-Homocysteines. Expand
Abnormal vitamin B6 status in rheumatoid cachexia. Association with spontaneous tumor necrosis factor alpha production and markers of inflammation.
OBJECTIVE To compare vitamin B6 levels in rheumatoid arthritis (RA) patients and healthy control subjects. METHODS We measured levels of vitamin B6 in 23 adults with well-controlled RA, and in 23Expand
Abnormal homocysteine metabolism in rheumatoid arthritis.
Elevated tHcy levels occur commonly in patients with RA, and may explain some of the increased cardiovascular mortality seen in such patients, and studies of the prevalence and mechanism of hyperhomocysteinemia in RA are warranted. Expand
Serum homocysteine and methylmalonic acid in patients with rheumatoid arthritis and cobalaminopenia.
The findings were compatible with the hypothesis that cobalaminopenia is one of several biochemical signs of gastrointestinal dysfunction in patients with severe RA, and it is suggested that the hyperhomocysteinemia associated with vitamin B12 deficiency, folate deficiency, vitamin B6 deficiency, and impaired renal function may have a role in promoting high cardiovascular morbidity in Patients with RA. Expand
Increased plasma levels of homocysteine and other thiol compounds in rheumatoid arthritis women.
The increased levels of thiol compounds found in rheumatoid arthritis patients may be implicated in the increased incidence of cardiovascular disease found in these patients by means of the toxic effect of homocysteine on endothelium and the increased susceptibility of LDL to oxidation by increased plasma amounts ofThiol compounds such as cysteine. Expand
Folic acid supplementation prevents deficient blood folate levels and hyperhomocysteinemia during longterm, low dose methotrexate therapy for rheumatoid arthritis: implications for cardiovascular disease prevention.
For longterm, low dose MTX therapy, there are now at least 3 reasons to consider supplementation with folic acid (a low cost prescription): to prevent MTX toxicity, to prevent or treat folate deficiency, and to prevent hyperhomocysteinemia. Expand
Activation of the immune system and inflammatory activity in relation to markers of atherothrombotic disease and atherosclerosis in rheumatoid arthritis.
That factor analysis showed loadings of one variable on antilipid antibodies and plaque and another on T cell activation and plaque indicates that the immune system is involved in the development of atherosclerosis in RA. Expand
Homocysteine and Cardiovascular Disease
After a thorough review of the available literature, it appears that hyperhomocysteinemia is an independent risk factor for CHD. Furthermore, folic acid has been shown to reduce homocysteineExpand
Anaemia in rheumatoid arthritis: the role of iron, vitamin B12, and folic acid deficiency, and erythropoietin responsiveness.
It was concluded that generally more than one type of anaemia is present simultaneously in anaemic patients with RA, and disease activity and, possibly, erythropoietin responsiveness are major factors in ACD pathogenesis. Expand
Cardiovascular morbidity and mortality in patients with seropositive rheumatoid arthritis in Northern Sweden.
The overall mortality and death due to CVD and IHD were in both sexes increased in seropositive RA, and male sex and high age at disease onset predicted death and cardiovascular event. Expand