Homocysteine impairs coronary artery endothelial function by inhibiting tetrahydrobiopterin in patients with hyperhomocysteinemia.

@article{He2010HomocysteineIC,
  title={Homocysteine impairs coronary artery endothelial function by inhibiting tetrahydrobiopterin in patients with hyperhomocysteinemia.},
  author={Liyun He and Hui Zeng and Fuwang Li and Jieli Feng and Shan Liu and Jinbo Liu and Jie Yu and Jieming Mao and Tianpei Hong and Alex F. Chen and Xian Wang and Guang Wang},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2010},
  volume={299 6},
  pages={E1061-5}
}
Hyperhomocysteinemia (HHcy) has been associated with impaired vascular endothelial function. Our previous study demonstrated significantly higher secretion of the chemokine monocyte chemoattractant protein-1 from monocytes in response to lipopolysaccharide in patients with HHcy. In the present study, we investigated whether coronary endothelial function was damaged in patients with chronic HHcy (plasma level of homocysteine >15 μmol/l) and, if so, whether this impaired endothelial function is… CONTINUE READING

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Noninvasive assessment of significant left anterior coronary E1064 HCY INHIBITS BH4 AND RESULTS IN ENDOTHELIAL DYSFUNCTION AJP-Endocrinol Metab

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