Homocysteine-dependent demethylation of trimethylselenonium ion and selenobetaine with methionine formation.

  title={Homocysteine-dependent demethylation of trimethylselenonium ion and selenobetaine with methionine formation.},
  author={D. E. Goeger and H. Ganther},
  journal={Archives of biochemistry and biophysics},
  volume={302 1},
  • D. E. Goeger, H. Ganther
  • Published 1993
  • Chemistry, Medicine
  • Archives of biochemistry and biophysics
  • In the presence of rat liver cytosol and homocysteine, trimethylselenonium ion (TMSe+) underwent time-dependent demethylation to dimethylselenide with the concurrent formation of methionine. Convenient methods were developed for assay of this activity using either radioactive methods based on the gamma emitting isotope 75Se or nonradioactive HPLC assay of methionine. The rate of demethylation was linear with protein concentration and dependent on homocysteine, which could not be replaced by… CONTINUE READING
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