Homocysteine associated genomic DNA hypermethylation in patients with chronic alcoholism
@article{Bnsch2004HomocysteineAG, title={Homocysteine associated genomic DNA hypermethylation in patients with chronic alcoholism}, author={Dominikus B{\"o}nsch and Bernd Lenz and Udo Reulbach and Johannes Kornhuber and Stefan Bleich}, journal={Journal of Neural Transmission}, year={2004}, volume={111}, pages={1611-1616} }
Summary.Higher plasma homocysteine concentrations can influence genomic DNA methylation in peripheral blood cells. In the present controlled study we observed a significant increase (10%) of genomic DNA methylation in patients with alcoholism (t = −3.16, df = 158, p = 0.002) which was significantly associated with their elevated homocysteine levels (multiple linear regression, p < 0.001). Since methylation of DNA is an important epigenetic factor in regulation of gene expression these findings…
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References
SHOWING 1-10 OF 14 REFERENCES
Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease.
- Medicine, BiologyClinical chemistry
- 2003
Global DNA methylation may be altered in vascular disease, with a concomitant increase in plasma tHcy and AdoHcy.
Increase in Plasma Homocysteine Associated with Parallel Increases in Plasma S-Adenosylhomocysteine and Lymphocyte DNA Hypomethylation*
- Biology, MedicineThe Journal of Biological Chemistry
- 2000
Chronic elevation in plasma homocysteine levels, such as those associated with nutritional deficiencies or genetic polymorphisms in the folate pathway, may have an indirect and negative effect on cellular methylation reactions through a concomitant increase in intracellular SAH levels.
Methylomics in psychiatry: Modulation of gene–environment interactions may be through DNA methylation
- BiologyAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
- 2004
DNA methylation usually increases with age, although hypomethylation of the promoter region of the amyloid A4 precursor gene during aging may play a role in Alzheimer's disease.
Oxidative stress and an altered methionine metabolism in alcoholism
- MedicineNeuroscience Letters
- 2000
Homocysteine as a neurotoxin in chronic alcoholism
- Medicine, BiologyProgress in Neuro-Psychopharmacology and Biological Psychiatry
- 2004
Alterations in DNA methylation: a fundamental aspect of neoplasia.
- BiologyAdvances in cancer research
- 1998
Elevated homocysteine levels in alcohol withdrawal.
- MedicineAlcohol and alcoholism
- 2000
It is postulate that hyperhomocysteinaemia and excitatory amino acid neurotransmitters, by their agonism at the N-methyl-D-aspartate receptor, may partly mediate alcohol-associated withdrawal symptomatology.
Homocysteine levels in patients classified according to Lesch's typology.
- MedicineAlcohol and alcoholism
- 2004
Homocysteine levels on admission may be a useful screening method to identify actively drinking patients at risk of alcohol withdrawal seizures, especially in alcoholics with Lesch type 1.
Homocysteine metabolism.
- BiologyAnnual review of nutrition
- 1999
The studies with animal models indicated the possibility that the effect of elevated homocysteine is multifactorial, affecting both the vascular wall structure and the blood coagulation system.