Homocysteine associated genomic DNA hypermethylation in patients with chronic alcoholism

@article{Bnsch2004HomocysteineAG,
  title={Homocysteine associated genomic DNA hypermethylation in patients with chronic alcoholism},
  author={Dominikus B{\"o}nsch and Bernd Lenz and Udo Reulbach and Johannes Kornhuber and Stefan Bleich},
  journal={Journal of Neural Transmission},
  year={2004},
  volume={111},
  pages={1611-1616}
}
Summary.Higher plasma homocysteine concentrations can influence genomic DNA methylation in peripheral blood cells. In the present controlled study we observed a significant increase (10%) of genomic DNA methylation in patients with alcoholism (t = −3.16, df = 158, p = 0.002) which was significantly associated with their elevated homocysteine levels (multiple linear regression, p < 0.001). Since methylation of DNA is an important epigenetic factor in regulation of gene expression these findings… 
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As hypermethylation of DNA is an important epigenetic factor in the down-regulation of gene expression, and as HERP has been considered to play an essential role within the intracellular defense system, these findings may be useful in the understanding and treatment of different disease conditions associated with alcohol dependence.
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