Homocysteine associated genomic DNA hypermethylation in patients with chronic alcoholism

  title={Homocysteine associated genomic DNA hypermethylation in patients with chronic alcoholism},
  author={Dominikus B{\"o}nsch and Bernd Lenz and Udo Reulbach and Johannes Kornhuber and Stefan Bleich},
  journal={Journal of Neural Transmission},
Summary.Higher plasma homocysteine concentrations can influence genomic DNA methylation in peripheral blood cells. In the present controlled study we observed a significant increase (10%) of genomic DNA methylation in patients with alcoholism (t = −3.16, df = 158, p = 0.002) which was significantly associated with their elevated homocysteine levels (multiple linear regression, p < 0.001). Since methylation of DNA is an important epigenetic factor in regulation of gene expression these findings… 
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Effect of alcohol consumption on peripheral blood Alu methylation in Korean men
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Increase in Plasma Homocysteine Associated with Parallel Increases in Plasma S-Adenosylhomocysteine and Lymphocyte DNA Hypomethylation*
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Methylomics in psychiatry: Modulation of gene–environment interactions may be through DNA methylation
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The studies with animal models indicated the possibility that the effect of elevated homocysteine is multifactorial, affecting both the vascular wall structure and the blood coagulation system.