Homocysteine associated genomic DNA hypermethylation in patients with chronic alcoholism

@article{Bnsch2004HomocysteineAG,
  title={Homocysteine associated genomic DNA hypermethylation in patients with chronic alcoholism},
  author={Dominikus B{\"o}nsch and Bernd Lenz and Udo Reulbach and Johannes Kornhuber and Stefan Bleich},
  journal={Journal of Neural Transmission},
  year={2004},
  volume={111},
  pages={1611-1616}
}

• Dominikus Bönsch, Bernd Lenz, +2 authors Stefan Bleich
• Published 2004 in Journal of Neural Transmission
• DOI:10.1007/s00702-004-0232-x

Higher plasma homocysteine concentrations can influence genomic DNA methylation in peripheral blood cells. In the present controlled study we observed a significant increase (10%) of genomic DNA methylation in patients with alcoholism (t = −3.16, df = 158, p = 0.002) which was significantly associated with their elevated homocysteine levels (multiple linear regression, p < 0.001). Since methylation of DNA is an important epigenetic factor in regulation of gene expression these findings may have… CONTINUE READING

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