Homocysteine as a predictive factor for hip fracture in older persons.

@article{McLean2004HomocysteineAA,
  title={Homocysteine as a predictive factor for hip fracture in older persons.},
  author={Robert R. McLean and Paul F. Jacques and Jacob Selhub and Katherine L. Tucker and Elizabeth J Samelson and Kerry E. Broe and Marian T Hannan and L. Adrienne Cupples and Douglas P. Kiel},
  journal={The New England journal of medicine},
  year={2004},
  volume={350 20},
  pages={
          2042-9
        }
}
BACKGROUND The increased prevalence of osteoporosis among people with homocystinuria suggests that a high serum homocysteine concentration may weaken bone by interfering with collagen cross-linking, thereby increasing the risk of osteoporotic fracture. We examined the association between the total homocysteine concentration and the risk of hip fracture in men and women enrolled in the Framingham Study. METHODS We studied 825 men and 1174 women, ranging in age from 59 to 91 years, from whom… 
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Findings suggest that the homocysteine concentration is an important risk factor for hip fractures in Parkinson's disease patients receiving levodopa.
Homocysteine and fracture prevention.
TLDR
Japanese patients following stroke who were treated with folate and vitamin B12 had a 5 times lower risk for hip fracture over a follow-up period of 2 years compared with the placebo group, which is a very large risk reduction, but care should be taken in interpreting these results.
Homocysteine, an additional factor, is linked to osteoporosis in postmenopausal women with type 2 diabetes
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The results suggest that plasma total homocysteine concentration is independently associated with the occurrence of osteoporosis in postmenopausal patients with type 2 diabetes.
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