Homocysteine and vitamin therapy in stroke prevention and treatment: a review.

  title={Homocysteine and vitamin therapy in stroke prevention and treatment: a review.},
  author={Bogdan Nicolae Manolescu and Eliza Oprea and Ileana Cornelia Farcasanu and Mihai Berteanu and Cornelia Cercasov},
  journal={Acta biochimica Polonica},
  volume={57 4},
Homocysteine (Hcy), a sulfur amino acid, is the only direct precursor for L-methionine synthesis through a reaction that requires vitamin B₁₂, representing a connection with "one-carbon" units metabolism. Hcy catabolism requires vitamin B₆ and as a consequence, alteration in folic acid and B vitamins status impairs Hcy biotransformation. Numerous studies have indicated that Hcy is an independent risk factor for cardio- and cerebrovascular diseases. In the last decade, several clinical trials… CONTINUE READING


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