Homocysteine and vascular disease: review of published results of the homocysteine-lowering trials

@article{Clarke2011HomocysteineAV,
  title={Homocysteine and vascular disease: review of published results of the homocysteine-lowering trials},
  author={Robert J. Clarke and Jim Halsey and Derrick A Bennett and Sarah Lewington},
  journal={Journal of Inherited Metabolic Disease},
  year={2011},
  volume={34},
  pages={83-91}
}
Moderately elevated homocysteine levels have been associated with a higher risk of cardiovascular disease in observational studies, but whether these associations are causal is uncertain. Randomized trials of dietary supplementation with B vitamins were set up to assess whether lowering homocysteine levels could reduce the risk of vascular disease. This review is based on a meta-analysis of published results of eight homocysteine-lowering trials for preventing vascular disease. The eight trials… 

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