Homocysteine and folate status in methotrexate-treated patients with rheumatoid arthritis.

@article{Ede2002HomocysteineAF,
  title={Homocysteine and folate status in methotrexate-treated patients with rheumatoid arthritis.},
  author={Annelies E van Ede and Roland F J Laan and Henk J Blom and Godfried H. J. Boers and Cees J. Haagsma and Chris M. G. Thomas and Theo M de Boo and L. B. A. van de Putte},
  journal={Rheumatology},
  year={2002},
  volume={41 6},
  pages={
          658-65
        }
}
  • Annelies E van Ede, Roland F J Laan, +5 authors L. B. A. van de Putte
  • Published in Rheumatology 2002
  • Medicine
  • OBJECTIVE To study (i) the influence of methotrexate (MTX) therapy on homocysteine and folate metabolism in patients with rheumatoid arthritis (RA), (ii) the influence of the C677T mutation in the methylenetetrahydrofolate reductase gene (MTHFR) on the change in plasma homocysteine levels during MTX treatment, and (iii) the interference of folate and homocysteine metabolism with the efficacy and toxicity of treatment with MTX. METHODS The 113 patients enrolled in this study were participating… CONTINUE READING

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