Homocysteine and cardiovascular disease.

  title={Homocysteine and cardiovascular disease.},
  author={Helga Refsum and Per Magne Ueland and Ottar K Nyg{\aa}rd and Stein Emil Vollset},
  journal={Annual review of medicine},
An elevated level of total homocysteine (tHcy) in blood, denoted hyperhomocysteinemia, is emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the coronary, cerebral, and peripheral vessels, and for arterial and venous thromboembolism. The basis for these conclusions is data from about 80 clinical and epidemiological studies including more than 10,000 patients. Elevated tHcy confers a graded risk with no threshold, is independent of but may enhance the effect… CONTINUE READING
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