Homocysteine and Folate Levels as Risk Factors for Recurrent Early Pregnancy Loss

@article{Nelen2000HomocysteineAF,
  title={Homocysteine and Folate Levels as Risk Factors for Recurrent Early Pregnancy Loss},
  author={Willianne L D M Nelen and Henk J Blom and Eric A. P. Steegers and Martin den Heijer and Chris M. G. Thomas and Tom K.A.B. Eskes},
  journal={Obstetrics \& Gynecology},
  year={2000},
  volume={95},
  pages={519–524}
}
Objective To estimate the relative risk of recurrent early pregnancy loss for different total plasma homocysteine and serum folate concentrations. Methods In a case-control study, we measured homocysteine (fasting and afterload), folate (serum and red cells), pyridoxal 5′-phosphate, and cobalamin concentrations in 123 women who had at least two consecutive spontaneous early pregnancy losses each and compared concentrations with those of 104 healthy controls. Results Women with recurrent early… 
Plasma folate levels and risk of spontaneous abortion.
TLDR
Low plasma folate levels were associated with an increased risk of early spontaneous abortion in case women with spontaneous abortion and controls.
Effect of homocysteine concentration in early pregnancy on gestational hypertensive disorders and other pregnancy outcomes.
TLDR
The finding of high tH Cy in early pregnancy as a risk factor for pregnancy loss and preeclampsia is consistent with a hypothesis that increased tHcy results in abnormalities of the placental vasculature.
Low serum vitamin B12 is associated with recurrent pregnancy loss in Syrian women
TLDR
Low serum vitamin B12 is confirmed in patients with recurrent abortion patients, however, methylmalonic acid did not support that functional vitamin B 12 plays a role in this group.
Plasma homocysteine levels correlated to interactions between folate status and methylene tetrahydrofolate reductase gene mutation in women with unexplained recurrent pregnancy loss
TLDR
The highest values of homocysteine concentration were found in women experiencing recurrent pregnancy loss with both the CT genotype and folate deficiency, and these values may help in therapeutic normalisation and might permit a normal birth.
Does serum homocysteine level have a role in the early pregnancy loss?
TLDR
High homocysteine levels detected during early weeks of gestation can be a warning about the miscarriage risk, and also may provide insight about the obstetric complications that may develop in the further weeks of pregnancy such as preeclampsia, ablatio placentae and intrauterine growth restriction.
Preconception B-vitamin and homocysteine status, conception, and early pregnancy loss.
TLDR
Poor vitamin B6 status appears to decrease the probability of conception and to contribute to the risk of early pregnancy loss in this population of textile workers from Anqing, China.
Low Vitamin B(12) level as a risk factor for very early recurrent abortion.
TLDR
Vitamin B( 12) deficiency may be involved in ERA and Vitamin B(12) supplementation led to four normal pregnancies in five women who became pregnant again and in a statistical analysis performed on five studies in which serum B (12) was assayed in ERA, a significant relationship was found.
Hyperhomocysteinemia and recurrent early pregnancy loss: a meta-analysis.
TLDR
The data support hyperhomocysteinemia as a risk factor for recurrent early pregnancy loss and further research should be focused on the pathophysiology of this relationship and on the clinical efficacy of B vitamin supplementation.
Preconception folate status and reproductive outcomes among a prospective cohort of folate-replete women.
TLDR
Examination of associations between preconceptional biomarkers of maternal folate status (folate and homocysteine) and reproductive outcomes in folate-replete women found no meaningful relationships were found between serum folate and any reproductive outcome or between plasma homocy steine and anovulation or becoming pregnant.
Preconception Folate and Vitamin B6 Status and Clinical Spontaneous Abortion in Chinese Women
TLDR
Suboptimal preconception folate and vitamin B6 status, especially when they occur together, may increase the risk of clinical spontaneous abortion in women from Anqing, China.
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References

SHOWING 1-10 OF 24 REFERENCES
Serum levels of folate and cobalamin in women with recurrent spontaneous abortion.
TLDR
The serum concentrations of folic acid and vitamin B12 are not significantly altered in women with unexplained recurrent spontaneous abortions, and an association between a deficiency of these vitamins and an increased risk of pregnancy loss appears to be questionable in the majority of gestations.
Hyperhomocysteinemia: a risk factor in women with unexplained recurrent early pregnancy loss.
TLDR
Hyperhomocysteinemia is a risk factor in women with unexplained recurrent early pregnancy loss and it is found that parous women of the study group were more than two times greater compared with the nulliparous subjects.
Folate Status and Pregnancy Outcome
TLDR
Investigating the folate status in some one hundred pregnant women in a longitudinal study by measuring folate in serum and erythrocytes found that folate deficiency itself might be one of the (predominant ?) factors in the etiology of abortion.
Methylenetetrahydrofolate reductase polymorphism affects the change in homocysteine and folate concentrations resulting from low dose folic acid supplementation in women with unexplained recurrent miscarriages.
To determine the effects of daily supplementation of 0.5 mg folic acid on homocysteine and folate concentrations, we investigated 49 women with a history of unexplained recurrent miscarriages. A
Haemostatic and metabolic abnormalities in women with unexplained recurrent abortion.
TLDR
It was concluded that parous women with a history of unexplained recurrent abortion have an increased incidence of hyperhomocysteinaemia and a trend of increase incidence of ACA can be found.
Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project.
TLDR
An increased plasma total homocysteine level confers an independent risk of vascular disease similar to that of smoking or hyperlipidemia, and compared with nonusers of vitamin supplements, the small number of subjects taking such vitamins appeared to have a substantially lower risk ofascular disease, a proportion of which was attributable to lower plasma homocy steine levels.
Serum folic level in abortion.
  • G. P. Dutta
  • Medicine
    Journal of the Indian Medical Association
  • 1977
TLDR
Anemia improved markedly in both groups, but was better in the combined therapy group, while Administration of massive doses of iron caused folic acid depletion and increased abortion incidence, and was prevented when folic Acid was given along with iron therapy.
A woman with five consecutive fetal deaths: case report and retrospective analysis of hyperhomocysteinemia prevalence in 100 consecutive women with recurrent miscarriages.
TLDR
Hyperhomocysteinemia should be identified in women with recurrent miscarriages because therapeutic normalization might permit a normal birth.
The effects of maternal folic acid and vitamin C nutrition in early pregnancy on reproductive performance in the guinea-pig.
TLDR
The short-term deficiency of either of these two vitamins, insufficient to affect maternal health, had a dramatic effect on the reproductive performance and the RDI of FA was significantly less effective than the supplemented intake in preventing embryonic deaths.
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