Homocysteine and B vitamins.

  title={Homocysteine and B vitamins.},
  author={Stacey Cook and O M Hess},
  journal={Handbook of experimental pharmacology},
Homocysteine (tHcy) is an intermediate sulfur-containing amino acid which acts as a methyl group donor for methionine metabolism. Increased serum concentrations (=hyperhomocysteinemia, >10 micromol/l) have been associated with an increased cardiovascular risk. Homocystinuria, an infrequent genetic disease usually due to lack of cystathione beta-synthase, has been found with severely elevated serum homocysteine values (>150 micromol/l). Functional gene polymorphisms of key enzymes (e.g., N5,N10… CONTINUE READING


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