Homocysteine and Alzheimer's disease

@article{Morris2003HomocysteineAA,
  title={Homocysteine and Alzheimer's disease},
  author={Martha Savaria Morris},
  journal={The Lancet Neurology},
  year={2003},
  volume={2},
  pages={425-428}
}
  • M. S. Morris
  • Published 1 July 2003
  • Medicine
  • The Lancet Neurology
BACKGROUND A high circulating concentration of the amino acid homocysteine is an independent risk factor for stroke. Alzheimer's disease (AD) commonly co-occurs with stroke. Epidemiological studies found associations between hyperhomocysteinaemia and both histologically confirmed AD and disease progression and revealed that dementia in AD was associated with evidence of brain infarcts on autopsy. Thus, hyperhomocysteinaemia and AD could be linked by stroke or microvascular disease. However… 
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TLDR
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TLDR
Blood inflammatory markers are associated with increased VaD risk but do not predict AD, which seems selectively associated with hyperhomocysteinemia, although this condition is associated with both inflammation and increased risk of dementia.
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TLDR
It is indicated that folate deficiency/possible deficiency increases the risk for AD, while sufficient intake of folate is a protective factor against AD.
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TLDR
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TLDR
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TLDR
The findings demonstrate that a dietary condition which leads to HHcy may also result in increased Abeta levels and deposition in a transgenic mouse model of AD-like amylodosis, and further support the concept that dietary factors can contribute to the development of AD neuropathology.
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TLDR
Dementia developed in 111 subjects, including 83 given a diagnosis of Alzheimer's disease, over a median follow-up period of eight years, and plasma levels of folate and vitamins B12 and B6 increased.
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