Homocysteine accumulation in human ovarian carcinoma ascitic/cystic fluids possibly caused by metabolic alteration of the methionine cycle in ovarian carcinoma cells.

@article{Corona1997HomocysteineAI,
  title={Homocysteine accumulation in human ovarian carcinoma ascitic/cystic fluids possibly caused by metabolic alteration of the methionine cycle in ovarian carcinoma cells.},
  author={Giuseppe Corona and G Toffoli and M. Fabris and Alessandra Viel and A Zarrelli and Carlo Donada and Mauro Boiocchi},
  journal={European journal of cancer},
  year={1997},
  volume={33 8},
  pages={1284-90}
}
The major role of the high-affinity folate-binding protein (FBP) is to regulate cellular folate homeostasis by increasing folate uptake in case of extracellular and intracellular folate deficiency. On this basis, we hypothesised that the overexpression of FBP in ovarian carcinoma might be physiologically associated with folate deficiency in the extracellular fluids, where ovarian carcinoma cells develop in vivo, or it might be the result of a reduced intracellular regeneration of the 5… CONTINUE READING

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