Homocysteine accelerates senescence and reduces proliferation of endothelial progenitor cells.

@article{Zhu2006HomocysteineAS,
  title={Homocysteine accelerates senescence and reduces proliferation of endothelial progenitor cells.},
  author={Jia Hao Zhu and Jun-zhu Chen and Xiao Xiong Wang and Xiangdong Xie and Jian Sun and Fu Rong Zhang},
  journal={Journal of molecular and cellular cardiology},
  year={2006},
  volume={40 5},
  pages={
          648-52
        }
}
Our previous studies showed that homocysteine (Hcy) reduces endothelial progenitor cell (EPC) numbers and impairs functional activity. However, the mechanisms by which Hcy reduces EPCs numbers and activity remain to be determined. Recent studies have demonstrated that reduced EPCs numbers and activity was associated with EPCs senescence which involved telomerase activity. Therefore, we investigated whether Hcy accelerates the onset of EPCs senescence through telomerase inactivation, leading to… CONTINUE READING
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