Homocysteine Triggers Inflammatory Responses in Macrophages through Inhibiting CSE-H2S Signaling via DNA Hypermethylation of CSE Promoter

@inproceedings{Li2015HomocysteineTI,
  title={Homocysteine Triggers Inflammatory Responses in Macrophages through Inhibiting CSE-H2S Signaling via DNA Hypermethylation of CSE Promoter},
  author={Jiao-Jiao Li and Qian Li and Hua-ping Du and Ya-Li Wang and Shou-jiang You and F Wang and Xing-Shun Xu and Jian Cheng and Yong-jun Cao and Chun-Feng Liu and Li-Fang Hu and Denis Girard},
  booktitle={International journal of molecular sciences},
  year={2015}
}
Hyperhomocysteinemia (HHcy) is an independent risk factor of atherosclerosis and other cardiovascular diseases. Unfortunately, Hcy-lowering strategies were found to have limited effects in reducing cardiovascular events. The underlying mechanisms remain unclear. Increasing evidence reveals a role of inflammation in the pathogenesis of HHcy. Homocysteine (Hcy) is a precursor of hydrogen sulfide (H2S), which is formed via the transsulfuration pathway catalyzed by cystathionine β-synthase and… CONTINUE READING