Homocysteine Potentiates Seizures and Cell Loss Induced by Pilocarpine Treatment

@article{Baldelli2009HomocysteinePS,
  title={Homocysteine Potentiates Seizures and Cell Loss Induced by Pilocarpine Treatment},
  author={Enrica Baldelli and Giuseppina Leo and Nicola Andreoli and Kjell Fuxe and Giuseppe Biagini and Luigi Francesco Agnati},
  journal={NeuroMolecular Medicine},
  year={2009},
  volume={12},
  pages={248-259}
}
Patients affected by recurrent seizures frequently present increased homocysteine plasma levels in consequence of treatment with antiepileptic drugs. Homocysteine is proconvulsant and can affect the response to antiepileptic drugs. In addition, high homocysteine plasma levels represent a risk factor for cardiovascular and neurodegenerative diseases. To better define the role of increased homocysteine in epilepsy, we analyzed the effects of homocysteine pretreatment in the pilocarpine model of… CONTINUE READING
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