Homocysteine Determinants and the Evidence to What Extent Homocysteine Determines the Risk of Coronary Heart Disease

@article{deBree2002HomocysteineDA,
  title={Homocysteine Determinants and the Evidence to What Extent Homocysteine Determines the Risk of Coronary Heart Disease},
  author={Angelika de Bree and W M Monique Verschuren and Daan Kromhout and Leo A. J. Kluijtmans and Henk J Blom},
  journal={Pharmacological Reviews},
  year={2002},
  volume={54},
  pages={599 - 618}
}
Cardiovascular diseases (CVD), especially coronary heart disease (CHD), are the most important causes of death in industrialized countries. Increased concentrations of total plasma homocysteine (tHcy) have been associated with an increased risk of CHD. Assuming that this relation is causal, a lower tHcy concentration will reduce the occurrence and recurrence of CHD. Therefore, it is important to know which factors determine the tHcy concentration. In the general population, the most important… Expand
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