Homocysteine: exploring its potential as a pharmacodynamic biomarker of antifolate chemotherapy.

@article{Valk2004HomocysteineEI,
  title={Homocysteine: exploring its potential as a pharmacodynamic biomarker of antifolate chemotherapy.},
  author={Dalibor Val{\'i}k and Martin Radina and Jaroslav {\vS}těrba and Borivoj Vojtesek},
  journal={Pharmacogenomics},
  year={2004},
  volume={5 8},
  pages={
          1151-62
        }
}
For decades it has been well known that elevated levels of homocysteine are harmful to humans on the basis of clinical observations derived from classical model diseases, such as inherited metabolic disorders. This group of diseases includes classical homocystinuria and several other inherited diseases affecting the so-called 'transsulfuration pathways'. Homocysteine lies in a metabolic checkpoint that interconnects one-carbon-transferring reactions with metabolism of sulfur-containing amino… Expand
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