Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism, and risk of retinal vein occlusion: a meta-analysis.

@article{McGimpsey2009HomocysteineMR,
  title={Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism, and risk of retinal vein occlusion: a meta-analysis.},
  author={Stuart J McGimpsey and Jayne V Woodside and Chris Cardwell and Mark Cahill and Usha Chakravarthy},
  journal={Ophthalmology},
  year={2009},
  volume={116 9},
  pages={1778-1787.e1}
}
OBJECTIVE To assess the role of plasma total homocysteine (tHcy) concentrations and homozygosity for the thermolabile variant of the methylenetetrahydrofolate reductase (MTHFR) C677T gene as risk factors for retinal vascular occlusive disease. DESIGN Retinal vein occlusion (RVO) is an important cause of vision loss. Early meta-analyses showed that tHcy was associated with an increased risk of RVO, but a significant number of new studies have been published. PARTICIPANTS AND/OR CONTROLS RVO… CONTINUE READING
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