Homocysteine, intracellular signaling and thrombotic disorders.

@article{Dionisio2010HomocysteineIS,
  title={Homocysteine, intracellular signaling and thrombotic disorders.},
  author={Natalia Dionisio and Isaac Jardin and Gin{\'e}s M Salido and Juan Antonio Rosado},
  journal={Current medicinal chemistry},
  year={2010},
  volume={17 27},
  pages={
          3109-19
        }
}
Homocysteine, a sulphur-containing amino acid derived from methionine, has been presented as an independent risk factor for cardiovascular disorders, including atherosclerosis and thrombogenesis. The mechanisms underlying homocysteine-induced effects have been intensively investigated over the last two decades. Homocysteine can induce oxidative stress promoting oxidant injury to vascular and blood cells. Hyperhomocysteinemia often results in intracellular Ca2+ mobilization, endoplasmic… CONTINUE READING

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