Homocamptothecin, an E-ring-modified camptothecin, exerts more potent antiproliferative activity than other topoisomerase I inhibitors in human colon cancers obtained from surgery and maintained in vitro under histotypical culture conditions.

@article{Philippart2000HomocamptothecinAE,
  title={Homocamptothecin, an E-ring-modified camptothecin, exerts more potent antiproliferative activity than other topoisomerase I inhibitors in human colon cancers obtained from surgery and maintained in vitro under histotypical culture conditions.},
  author={Pierre Philippart and Luke Harper and Carole Chaboteaux and Christine Decaestecker and Yves Bronckart and L Gordover and Laurence Lesueur-Ginot and Hugues Malonne and Olivier Lavergne and Dennis C. H. Bigg and Patr{\'i}cia Marçal da Costa and Robert Kiss},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2000},
  volume={6 4},
  pages={1557-62}
}
Topoisomerase I (Topo I) is overexpressed in cancer colon tissues compared with normal colon tissues. Several anti-Topo I inhibitors are already successfully used in the clinic. We illustrate here the antiproliferative activity of a new class of Topo I inhibitors, i.e., E-ring-modified camptothecins with enhanced lactone stability (L. Lesueur-Ginot et al., Cancer Res., 59: 2939-2943, 1999). Forty-three human colon cancers were obtained from surgical resection and maintained under organotypical… CONTINUE READING

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