Homing of immune cells: role in homeostasis and intestinal inflammation.

@article{Hart2010HomingOI,
  title={Homing of immune cells: role in homeostasis and intestinal inflammation.},
  author={Ailsa L. Hart and Siew C Ng and Elizabeth R. Mann and Hafid Omar Al-Hassi and David Bernardo and Stella C. Knight},
  journal={Inflammatory bowel diseases},
  year={2010},
  volume={16 11},
  pages={
          1969-77
        }
}
Rather like a satellite navigation system directing a vehicle to a particular destination defined by post-code, immune cells have homing molecules or "immune post-codes" enabling them to be recruited to specific organs, such as the intestine or skin. An efficient system would be designed such that the site of entry of an antigen influences the homing of effector T cells back to the appropriate organ. For example, to mount an immune response against an intestinal pathogen, T cells with a… CONTINUE READING

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