Homing endonuclease structure and function

@article{Stoddard2005HomingES,
  title={Homing endonuclease structure and function},
  author={Barry L. Stoddard},
  journal={Quarterly Reviews of Biophysics},
  year={2005},
  volume={38},
  pages={49 - 95}
}
  • B. Stoddard
  • Published 1 February 2005
  • Biology
  • Quarterly Reviews of Biophysics
Homing endonucleases are encoded by open reading frames that are embedded within group I, group II and archael introns, as well as inteins (intervening sequences that are spliced and excised post-translationally). These enzymes initiate transfer of those elements (and themselves) by generating strand breaks in cognate alleles that lack the intervening sequence, as well as in additional ectopic sites that broaden the range of intron and intein mobility. Homing endonucleases can be divided into… 

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Homing endonucleases from archaea introns, protein insertions, and the mobile group I introns from organelles share a common motif, the LAGLI-DADG motif, which makes them attractive tools for mapping of large genomes.

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TLDR
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  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
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TLDR
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TLDR
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