Homer2 within the nucleus accumbens core bidirectionally regulates alcohol intake by both P and Wistar rats.

@article{Haider2015Homer2WT,
  title={Homer2 within the nucleus accumbens core bidirectionally regulates alcohol intake by both P and Wistar rats.},
  author={Arshad Haider and Nicholas C Woodward and Kevin D. Lominac and Arianne D Sacramento and Matthias Klugmann and Richard L. Bell and K K Szumlinski},
  journal={Alcohol},
  year={2015},
  volume={49 6},
  pages={533-42}
}
In murine models of alcoholism, the glutamate receptor scaffolding protein Homer2 bidirectionally regulates alcohol intake. Although chronic alcohol drinking increases Homer2 expression within the core subregion of the nucleus accumbens (NAc) of alcohol-preferring P rats, the relevance of this neuroadaptation for alcohol intake has yet to be determined in rats. Thus, the present study employed an adeno-associated viral vector (AAV) strategy to over-express and knock down the major rodent… CONTINUE READING