Homer1a drives homeostatic scaling-down of excitatory synapses during sleep

@article{Diering2017Homer1aDH,
  title={Homer1a drives homeostatic scaling-down of excitatory synapses during sleep},
  author={Graham Hugh Diering and Raja Sekhar Nirujogi and Richard H Roth and Paul F Worley and Akhilesh Pandey and Richard L. Huganir},
  journal={Science},
  year={2017},
  volume={355},
  pages={511-515}
}
Sleep is an essential process that supports learning and memory by acting on synapses through poorly understood molecular mechanisms. Using biochemistry, proteomics, and imaging in mice, we find that during sleep, synapses undergo widespread alterations in composition and signaling, including weakening of synapses through removal and dephosphorylation of synaptic AMPA-type glutamate receptors. These changes are driven by the immediate early gene Homer1a and signaling from group I metabotropic… CONTINUE READING

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ACKNOWLEDGMENTS All proteomics

I. Hong, S. Heo
Neuron 90, • 2016
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