Homer1a drives homeostatic scaling-down of excitatory synapses during sleep.


Sleep is an essential process that supports learning and memory by acting on synapses through poorly understood molecular mechanisms. Using biochemistry, proteomics, and imaging in mice, we find that during sleep, synapses undergo widespread alterations in composition and signaling, including weakening of synapses through removal and dephosphorylation of… (More)
DOI: 10.1126/science.aai8355


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