Homer Regulates the Association of Group 1 Metabotropic Glutamate Receptors with Multivalent Complexes of Homer-Related, Synaptic Proteins

@article{Xiao1998HomerRT,
  title={Homer Regulates the Association of Group 1 Metabotropic Glutamate Receptors with Multivalent Complexes of Homer-Related, Synaptic Proteins},
  author={Bo Xiao and Jian Cheng Tu and Ronald S. Petralia and Joseph P. Yuan and Andrew Doan and Christopher D Breder and Alicia M Ruggiero and Anthony A. Lanahan and Robert J. Wenthold and Paul F. Worley},
  journal={Neuron},
  year={1998},
  volume={21},
  pages={707-716}
}

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TLDR
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The Homer-1 protein Ania-3 interacts with the plasma membrane calcium pump.
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References

SHOWING 1-10 OF 51 REFERENCES
Homer: a protein that selectively binds metabotropic glutamate receptors
TLDR
A novel dendritic protein, Homer, is reported that contains a single, PDZ-like domain and binds specifically to the carboxy terminus of phosphoinositide-linked metabotropic glutamate receptors, suggesting that Homer mediates a novel cellular mechanism that regulates glutamate signalling.
Transcription Factor Regulation In Brain: Focus on Activity and NMDA Dependent Regulation
TLDR
A set of transcription factors that are regulated by synaptic activity and NMDA receptors and therefore may play a role in neuroplasticity are identified and examined.
Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein
TLDR
It is shown that a approximately 20S polypeptide complex (referred to as Activator I) stimulates dynein- mediated vesicle transport and proposes the name dynactin (for dyne in activator), which is required for in vitro vesicles motility.
...
1
2
3
4
5
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