Homer Regulates Gain of Ryanodine Receptor Type 1 Channel Complex*

  title={Homer Regulates Gain of Ryanodine Receptor Type 1 Channel Complex*},
  author={Wei Feng and Jiancheng Tu and Tianzhong Yang and Patty S Vernon and Paul D. Allen and Paul F. Worley and Isaac N. Pessah},
  journal={The Journal of Biological Chemistry},
  pages={44722 - 44730}
Homer proteins form an adapter system that regulates coupling of group 1 metabotropic glutamate receptors with intracellular inositol trisphosphate receptors and is modified by neuronal activity. Here, we demonstrate that Homer proteins also physically associate with ryanodine receptors type 1 (RyR1) and regulate gating responses to Ca2+, depolarization, and caffeine. In contrast to the prevailing notion of Homer function, Homer1c (long form) and Homer1-EVH1 (short form) evoke similar changes… 

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  • 2002
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