Homer Regulates Gain of Ryanodine Receptor Type 1 Channel Complex*

@article{Feng2002HomerRG,
  title={Homer Regulates Gain of Ryanodine Receptor Type 1 Channel Complex*},
  author={Wei Feng and Jiancheng Tu and Tianzhong Yang and Patty S Vernon and Paul D. Allen and Paul F. Worley and Isaac N. Pessah},
  journal={The Journal of Biological Chemistry},
  year={2002},
  volume={277},
  pages={44722 - 44730}
}
Homer proteins form an adapter system that regulates coupling of group 1 metabotropic glutamate receptors with intracellular inositol trisphosphate receptors and is modified by neuronal activity. Here, we demonstrate that Homer proteins also physically associate with ryanodine receptors type 1 (RyR1) and regulate gating responses to Ca2+, depolarization, and caffeine. In contrast to the prevailing notion of Homer function, Homer1c (long form) and Homer1-EVH1 (short form) evoke similar changes… 
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Homer Protein Increases Activation of Ca2+ Sparks in Permeabilized Skeletal Muscle*
TLDR
The results suggest that the EVH1 domain is critical for the agonist behavior on Ca2+ sparks and ryanodine binding, and that the coiled-coil domain, present in long but not short form Homer, confers an increase in agonist potential apparently through the multimeric association of Homer ligand.
Homer and the ryanodine receptor
TLDR
There are consensus sequences for Homer binding in the RyR and on many of the proteins that it interacts with in the massive RyR ion channel complex that also involve RyR channels.
Interaction of the Homer1 EVH1 domain and skeletal muscle ryanodine receptor.
In vitro modulation of the cardiac ryanodine receptor activity by Homer1
TLDR
The strong functional interactions suggest that Homer1 is likely to be an endogenous modulator of RyR channels in the heart and neurons as well as in skeletal muscle.
Homer proteins in Ca2+ signaling by excitable and non-excitable cells.
Conditions associated with ER dysfunction activate homer 1a expression
TLDR
It is shown that homer 1a expression is induced in neuronal cell cultures under experimental conditions associated with ER dysfunction and may be activated by impairment of ER functioning just as it is by glutamate receptor activation.
Dynamic regulation of ryanodine receptor type 1 (RyR1) channel activity by Homer 1.
Homer Binds TRPC Family Channels and Is Required for Gating of TRPC1 by IP3 Receptors
Vesl/Homer proteins regulate ryanodine receptor type 2 function and intracellular calcium signaling.
Homer2 Protein Regulates Plasma Membrane Ca2+-ATPase-mediated Ca2+ Signaling in Mouse Parotid Gland Acinar Cells*
TLDR
The role of Homer2 on Ca2+ signaling in parotid gland acinar cells using Homer2-deficient (Homer2−/−) mice is investigated and a Homer-binding PPXXF-like motif in the N terminus of PMCA that is required for interaction with Homer2 is identified.
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References

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Homer: a protein that selectively binds metabotropic glutamate receptors
TLDR
A novel dendritic protein, Homer, is reported that contains a single, PDZ-like domain and binds specifically to the carboxy terminus of phosphoinositide-linked metabotropic glutamate receptors, suggesting that Homer mediates a novel cellular mechanism that regulates glutamate signalling.
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Transmembrane Redox Sensor of Ryanodine Receptor Complex*
TLDR
This study reveals the existence of a transmembrane redox sensor within the RyR1 channel complex that confers tight regulation of channel activity in response to changes in transmem BRO redox potential produced by cytoplasmic and luminal glutathione.
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TLDR
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TLDR
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  • U. Thomas
  • Biology
    Journal of neurochemistry
  • 2002
TLDR
This review will address primarily more recent studies on the regulation of Homer’1a expression and on the role of Homer/Vesl proteins in spine morphogenesis and receptor targeting and signalling.
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TLDR
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