Homer Regulates Gain of Ryanodine Receptor Type 1 Channel Complex*

@article{Feng2002HomerRG,
  title={Homer Regulates Gain of Ryanodine Receptor Type 1 Channel Complex*},
  author={Wei Feng and Jiancheng Tu and Tianzhong Yang and Patty S Vernon and Paul D. Allen and Paul F. Worley and Isaac N. Pessah},
  journal={The Journal of Biological Chemistry},
  year={2002},
  volume={277},
  pages={44722 - 44730}
}
Homer proteins form an adapter system that regulates coupling of group 1 metabotropic glutamate receptors with intracellular inositol trisphosphate receptors and is modified by neuronal activity. Here, we demonstrate that Homer proteins also physically associate with ryanodine receptors type 1 (RyR1) and regulate gating responses to Ca2+, depolarization, and caffeine. In contrast to the prevailing notion of Homer function, Homer1c (long form) and Homer1-EVH1 (short form) evoke similar changes… 

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Conditions associated with ER dysfunction activate homer 1a expression
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It is shown that homer 1a expression is induced in neuronal cell cultures under experimental conditions associated with ER dysfunction and may be activated by impairment of ER functioning just as it is by glutamate receptor activation.
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Homer2 Protein Regulates Plasma Membrane Ca2+-ATPase-mediated Ca2+ Signaling in Mouse Parotid Gland Acinar Cells*
TLDR
The role of Homer2 on Ca2+ signaling in parotid gland acinar cells using Homer2-deficient (Homer2−/−) mice is investigated and a Homer-binding PPXXF-like motif in the N terminus of PMCA that is required for interaction with Homer2 is identified.
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TLDR
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TLDR
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