Homer Binds a Novel Proline-Rich Motif and Links Group 1 Metabotropic Glutamate Receptors with IP3 Receptors

@article{Tu1998HomerBA,
  title={Homer Binds a Novel Proline-Rich Motif and Links Group 1 Metabotropic Glutamate Receptors with IP3 Receptors},
  author={J. Tu and B. Xiao and Joseph Yuan and A. Lanahan and Kathleen Leoffert and M. Li and D. Linden and P. Worley},
  journal={Neuron},
  year={1998},
  volume={21},
  pages={717-726}
}
Group I metabotropic glutamate receptors (mGluRs) activate PI turnover and thereby trigger intracellular calcium release. Previously, we demonstrated that mGluRs form natural complexes with members of a family of Homer-related synaptic proteins. Here, we present evidence that Homer proteins form a physical tether linking mGluRs with the inositol trisphosphate receptors (IP3R). A novel proline-rich "Homer ligand" (PPXXFr) is identified in group 1 mGluRs and IP3R, and these receptors… Expand
826 Citations
Homer–PIKE complex: a novel link between mGluRI and PI 3-kinase
Homer as Both a Scaffold and Transduction Molecule
A new technique to co-localise membrane proteins with Homer/vesl.
Homer Regulates Gain of Ryanodine Receptor Type 1 Channel Complex*
Coupling of mGluR/Homer and PSD-95 Complexes by the Shank Family of Postsynaptic Density Proteins
Dynamic Regulation of Homer Binding to Group I Metabotropic Glutamate Receptors by Preso1 and Converging Kinase Cascades
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 165 REFERENCES
Homer Regulates the Association of Group 1 Metabotropic Glutamate Receptors with Multivalent Complexes of Homer-Related, Synaptic Proteins
Homer: a protein that selectively binds metabotropic glutamate receptors
RGS4 Inhibits Signaling by Group I Metabotropic Glutamate Receptors
Dynamic Regulation of RGS2 Suggests a Novel Mechanism in G-Protein Signaling and Neuronal Plasticity
Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1
...
1
2
3
4
5
...