Homer 2 tunes G protein–coupled receptors stimulus intensity by regulating RGS proteins and PLCβ GAP activities

  title={Homer 2 tunes G protein–coupled receptors stimulus intensity by regulating RGS proteins and PLCβ GAP activities},
  author={Dong Min Shin and Marlin Dehoff and Xiang Luo and Shin H Kang and Jiangchen Tu and Surendra Kumar Nayak and Elliott M. Ross and Paul F Worley and Shmuel Muallem},
  journal={The Journal of Cell Biology},
  pages={293 - 303}
Homers are scaffolding proteins that bind G protein-coupled receptors (GPCRs), inositol 1,4,5-triphosphate (IP3) receptors (IP3Rs), ryanodine receptors, and TRP channels. However, their role in Ca2+ signaling in vivo is not known. Characterization of Ca2+ signaling in pancreatic acinar cells from Homer2-/- and Homer3-/- mice showed that Homer 3 has no discernible role in Ca2+ signaling in these cells. In contrast, we found that Homer 2 tunes intensity of Ca2+ signaling by GPCRs to regulate the… CONTINUE READING


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